1 Evolution of substrate specificity for the bile salt transporter ABST ( SLC 10 A 2 )
نویسندگان
چکیده
Address correspondence to: Shi-Ying Cai, Ph.D., Liver Center, Yale University School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06520. Tel: (203)785-3150; Fax: (203)785-7273; E-mail: [email protected], or James L. Boyer, M.D. Ensign Professor of Medicine, Emeritus Director, Liver Center, Yale University School of Medicine, 333 Cedar Street, 1080 LMP, New Haven, CT 06520-8019. Phone: (203)785-5279; Fax: (203)7857273; email: [email protected]
منابع مشابه
Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]
The apical Na(+)-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile salt structure during evolution. We characterized ASBT orthologs from two primitive vertebrates, the lamprey that utilizes early 5α-bile alcohols ...
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Journal of Lipid Research Volume 53, 2012 1535 Copyright © 2012 by the American Society for Biochemistry and Molecular Biology, Inc. They facilitate lipid absorption, inhibit microbe growth in the biliary tract and intestine, and function as signaling molecules that regulate energy expenditure and carbohydrate and lipid metabolism ( 2 ). The bile salt pool is maintained in an enterohepatic circ...
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It has been proposed that the hepatocellular Na+-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na+-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. To characterize its substrate specificity Ntcp was stably transf...
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Background Bile salts undergo enterohepatic circulation which is essential for bile salt homeostasis. From the biliary tract, they are excreted into the small intestine, absorbed into the blood and transported back to the liver. The sinusoidal uptake systems of the liver efficiently extract bile salts and other substrates from portal blood. In rat liver, these systems include Ntcp (sodium tauro...
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